The Evaluation of Diastolic Dysfunction with Tissue Doppler Echocardiography in Women with Subclinical Hypothyroidism and the Effect of L-Thyroxine Treatment on Diastolic Dysfunction: A Pilot Study
نویسندگان
چکیده
Background. Subclinical hypothyroidism (SH) predominantly affects women. The necessity of treatment in SH is controversial. Objective. We aimed to investigate the response of diastolic dysfunction to thyroid hormone replacement therapy (THRT) in women. Methods and Results. Twenty-two female subjects with SH and 20 euthyroid female controls were enrolled. Baseline and follow-up biochemical, hormonal, and echocardiographic evaluations were performed. Repeat echocardiograms were performed three months after the achievement of a euthyroid status with THRT. Mean baseline myocardial performance index (MPI) was 0.27 ± 0.08 in the SH group, and 0.22 ± 0.06 in the control group (P = 0.03). MPI did not change significantly after THRT. Pulsed-wave Doppler findings were not different among the groups. However, tissue Doppler-derived mitral annular E' velocities were significantly lower in the SH group. A moderate but significant improvement was observed in E' velocities after THRT (13.2 ± 3.87 versus 14.53 ± 2.75, P = 0.04). We also observed left ventricular concentric remodeling in SH patients which was reversible with THRT. Conclusions. Tissue Doppler echocardiography may be a useful tool for monitoring the response of diastolic dysfunction to thyroid hormone replacement therapy in patients with SH. Our findings suggest that THRT may reverse diastolic dysfunction in women with SH.
منابع مشابه
The influence of Asthma on Right Ventricular Systolic and Diastolic Function in Children according to Tissue Doppler Echocardiography
Introduction:Asthma is the most common chronic inflammatory condition affecting the lower airways among children. Asthma may influence right ventricular (RV) function and patients may develop right ventricular hypertrophy, pulmonary hypertension and cor pulmonale. The main objective of this study is to determine RV dysfunction in asymptomatic asthmatic children as detected by ti...
متن کاملEchocardiographic left ventricular functional changes in acute hypothyroidism vs. subclinical hyperthyroidism in patients with differentiated thyroid carcinoma
Introduction: In order to assess echocardiographic left ventricular functional indices in patients with differentiated thyroid carcinoma (DTC), after L-T4 withdrawal (short-term overt hypothyroidism) and during TSH suppressive therapy, we have evaluated cardiac hemodynamics in a single cohort study. Methods: 24 patients with DTC were studied in two phases: 1: at least 4 weeks after L-T4 withd...
متن کاملبررسی عوارض قلبی در بیماران مبتلا به تالاسمی ماژور در کاشان در سالهای 1378 لغایت 1379
ABSTRACT Due to the frequency of major thalassemia in our country and cardiac complications secondry to iron overload as one of the most important causes of death in these patients and the absence of any similar study in this region (Kashan city), we studied the cardiac complications in patients with major thalassemia in Kashan in 1999 and 2000. A prospective descriptive study was perf...
متن کاملبررسی ارتباط بین پروتئین واکنشی c فوق حساس (HS-CRP) با عملکرد دیاستولیک قلب در بیماران مبتلا به پرفشاری خون اولیه مراجعهکننده به کلینیک تخصصی قلب شهر ایلام در سال 1392
Background: hypertension is a common disease and is asymptomatic and is easily diagnosed and easily treated, but if untreated, leads to fatal complications in patients are concerned. Causing the deaths of 6% in the world. Methods: This case-control study (Case-Control) was performed. The study population included patients with primary hypertension who were referred to specialized clinics of ...
متن کاملThe Effect of Bronchial Asthma on Interatrial Electromechanical Delay Coupling Obtained Using Tissue Doppler Imaging
Background: Asthma is a predisposing factor for the development of atrial fibrillation. Asthma disturbs the electrophysiology in the right and left atrium. The aim of this study was to evaluate atrial electromechanical delay by coupling obtained from tissue Doppler imaging (TDI) in children. Methods: A cross-sectional study was conducted on 50 patients with Bronchial Asthma, compared with 50 hea...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 2011 شماره
صفحات -
تاریخ انتشار 2011